Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells.

TitleDirect Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells.
Publication TypeJournal Article
Year of Publication2022
AuthorsColarusso JL, Zhou Q
JournalCell Reprogram
Date Published2022 10
KeywordsCell Lineage, Cellular Reprogramming, Diabetes Mellitus, Glucose, Humans, Insulin, Insulin-Secreting Cells, Pancreas

One major goal of regenerative medicine is the production of pancreatic endocrine islets to treat insulin-dependent diabetic patients. Among the different methods developed to achieve this goal, a particularly promising approach is direct lineage reprogramming, in which non-β-cells are directly converted to glucose-responsive, insulin-secreting β-like cells. Efforts by different research groups have led to critical insights in the inducing factors necessary and types of somatic tissues suitable for direct conversion to β-like cells. Nevertheless, there is limited understanding of the molecular mechanisms underlying direct cell fate conversion. Significant challenges also remain in translating discoveries into therapeutics that will eventually benefit diabetic patients. This review aims to cover the advances made in the direct reprogramming of somatic cells into β-like cells and discuss the remaining challenges.

Alternate JournalCell Reprogram
PubMed ID35838597
PubMed Central IDPMC9634980
Grant ListR01 DK106253 / DK / NIDDK NIH HHS / United States
UC4 DK116280 / DK / NIDDK NIH HHS / United States