Title | Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Colarusso JL, Zhou Q |
Journal | Cell Reprogram |
Volume | 24 |
Issue | 5 |
Pagination | 252-258 |
Date Published | 2022 10 |
ISSN | 2152-4998 |
Keywords | Cell Lineage, Cellular Reprogramming, Diabetes Mellitus, Glucose, Humans, Insulin, Insulin-Secreting Cells, Pancreas |
Abstract | One major goal of regenerative medicine is the production of pancreatic endocrine islets to treat insulin-dependent diabetic patients. Among the different methods developed to achieve this goal, a particularly promising approach is direct lineage reprogramming, in which non-β-cells are directly converted to glucose-responsive, insulin-secreting β-like cells. Efforts by different research groups have led to critical insights in the inducing factors necessary and types of somatic tissues suitable for direct conversion to β-like cells. Nevertheless, there is limited understanding of the molecular mechanisms underlying direct cell fate conversion. Significant challenges also remain in translating discoveries into therapeutics that will eventually benefit diabetic patients. This review aims to cover the advances made in the direct reprogramming of somatic cells into β-like cells and discuss the remaining challenges. |
DOI | 10.1089/cell.2022.0048 |
Alternate Journal | Cell Reprogram |
PubMed ID | 35838597 |
PubMed Central ID | PMC9634980 |
Grant List | R01 DK106253 / DK / NIDDK NIH HHS / United States UC4 DK116280 / DK / NIDDK NIH HHS / United States |