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A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin. https://doi.org/10.1038/s41467-024-47738-y

Dr. Qiao Joe Zhou presented "The Molecular Machinery Controlling Stem Cell and Tissue Plasticity Between Adult Colon and Small Intestine".

Dr. Xiaofeng Steve Huang presented "Redirecting differentiation of human stomach stem cells to produce pancreatic islet-like organoids for diabetes treatment".

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Kim

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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

https://pubmed.ncbi.nlm.nih.gov/34582804/

Speaker: Dr. Wei Gu

Reference: SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodelingWei Gu, Hua Wang, Xiaofeng Huang, Judith Kraiczy, Pratik NP Singh, Charles Ng, Sezin Dagdeviren, Sean Houghton, Oscar Pellon-Cardenas, Ying Lan, Yaohui Nie, Jiaoyue Zhang, Kushal K Banerjee, Emily J Onufer, Brad W Warner, Jason Spence, Ellen Scherl,...

https://www.nature.com/articles/d41586-020-01801-y

Forkhead BioTherapeutics is a spin-off from Columbia University in New York City.

You can’t live without insulin. When people with type 1 diabetes lose their ability to produce this hormone, they need to inject synthetic insulin multiple times a day and closely monitor their blood sugar levels. Managing the disease is difficult, and people with diabetes are at high...

Until the day it dies, a cell that has become a skin cell remains a skin cell — or so scientists used to think. Over the past decade, it has become clear that cel- lular identity is not written in stone but can be rewritten by activating specific genetic pro- grams. Today, the field of regenerative medi- cine faces a question: should this rewriting take...

Lab TV News – Video Interview – 2016

"Mini-Stomach" can end Insulin Shots